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A unique serum on the market that rejuvenates the skin by improving sagging, wrinkles, dark spots, and texture. Retinal Renewal 0.3% GF&Peptide Serum modulates the interrelated mechanisms of protection, renewal, and depigmentation as a key therapeutic strategy in addressing advanced skin aging.
Formulated with the four most powerful active ingredients:
Pure encapsulated retinal for greater stability and penetration, providing you with the highest overall anti-aging efficacy.
Pureoxin™ is the growth factor that participates in the body's internal antioxidant balance by reducing inflammation by neutralizing oxidative stress generated by ultraviolet radiation and pollutants.
Dimethylmethoxy Chromanol, a molecule with notable effectiveness in neutralizing oxygen and nitrogen radicals, which cause cell damage and deterioration of the dermis structures.
Nonapeptide-1, a depigmenting peptide that effectively blocks melanogenesis by inhibiting tyrosinase and melanin synthesis. It reverses the pigment accumulation effects associated with photoaging.
Benefits:
It stimulates collagen and improves firmness.
Anti-wrinkle.
It improves skin texture and blurs pores.
It evens out skin tone.
It reverses photoaging.
Antioxidant.
Highest individual values in the study over 28 days* in:
Wrinkles: -74%
Melanin reduction: -80%
*In vivo test for the anti-wrinkle and depigmenting efficacy of Retinal Renewal 0.3% Growth Factor & Peptide Serum on 31 subjects (men and women, 40-69 years old) for 28 days. COD.REF.M-25-049418.
How to use:
Apply at night to the skin of the face and neck.
Recommendation:
Use gradually for greater tolerance:
Use three times a week for the first week.
For the next 2 weeks, apply on alternate days, one day yes and one day no.
From the 4th week of use, apply every night.
Very important:
Apply SPF50+ sunscreen in the morning throughout the treatment.
Recommendations:
In case of retinoid dermatitis (irritation, dryness, redness), use products such as the Biodefense range to strengthen the skin barrier.
What benefits does Primaderm Retinal Renewal 03 GF Peptide Serum offer?
Translated by Google
-13/10/2026
Designed to renew facial microarchitecture, it offers the following technical properties: • Repairing and regenerating properties that reduce the depth of wrinkles and expression lines. • Restructuring action that firms the skin tissue and improves overall elasticity. • Optimizes skin tone and texture for a smoother, more even, and luminous finish.
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What is the recommended usage and retinization guidelines?
Translated by Google
-14/06/2026
Gradually introduce into your nighttime routine on clean, dry skin, starting with two applications per week and increasing the frequency as tolerated. Spread thoroughly over the face and neck, avoiding the eye area.
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What skin conditions or anti-aging needs is this serum indicated for?
Translated by Google
-30/03/2026
Prescribed for skin that shows accelerated signs of aging, loss of density, deep wrinkles, uneven texture or lack of firmness that require an intensive transformative treatment.
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How does Primaderm’s Retinal Renewal 03 GF Peptide Serum work on skin tissue?
Translated by Google
-07/02/2026
It intervenes in the deep layers, accelerating cell renewal through retinaldehyde, while growth factors and peptides biologically stimulate the synthesis of collagen and elastin to restructure the extracellular matrix.
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